Genetics of osteoporosis from genome-wide association studies: advances and challenges

@article{Richards2012GeneticsOO,
  title={Genetics of osteoporosis from genome-wide association studies: advances and challenges},
  author={J Brent Richards and Hou-Feng Zheng and Tim D. Spector},
  journal={Nature Reviews Genetics},
  year={2012},
  volume={13},
  pages={576-588}
}
Osteoporosis is among the most common and costly diseases and is increasing in prevalence owing to the ageing of our global population. Clinically defined largely through bone mineral density, osteoporosis and osteoporotic fractures have reasonably high heritabilities, prompting much effort to identify the genetic determinants of this disease. Genome-wide association studies have recently provided rapid insights into the allelic architecture of this condition, identifying 62 genome-wide… CONTINUE READING
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