Genetics of Multiple Sclerosis
- BiologyGenetics of Rare Autoimmune Diseases
The genome-wide association studies in MS in large populations in combination with expression quantitative loci (eQTL) and a better understanding of the functional elements in the human genome have promoted a deeper knowledge of MS genetics in the last 10 years, but the genetic implication in the disease is still far from understanding.
Multiple sclerosis: could it be an epigenetic disease?
- Biology, MedicineMedical hypotheses
NOS2A as a candidate gene in Relapsing–Remitting Multiple Sclerosis: A haplotype study using selected subsets of single nucleotide polymorphisms
- BiologyJournal of the Neurological Sciences
IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients
- Biology, PsychologyEuropean Journal of Human Genetics
The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families and analyzed using the transmission/disequilibrium test.
Preliminary evidences of a NOS2A protective effect from Relapsing–Remitting Multiple Sclerosis
- Biology, MedicineJournal of the Neurological Sciences
Research Article Awareness rate of Ardabil city people about multiple sclerosis
Results showed that the knowledge rate of people about MS was in moderate and lower levels, so, present educational programs and increasing knowledge rate about MS by TV and radio programs is necessary.
ROLES OF FAS IN NEURAL PROGENITOR CELL DIFFERENTIATION, SURVIVAL, AND IMMUNE-CELL INTERACTIONS
The studies suggest the Fas system plays multifaceted roles in NPCs and that its exact functions are dependent on both functional Fas expression and presence or absence of FasL, and the main mechanism through which NPCs produce beneficial results in EAE is via peripheral immunoregulation, which is not dependent on Fas expression.
Characterization of D6S2806 and D6S2879 short tandem repeat loci in HLA-DRB1 region in Iranian population.
- BiologyTissue antigens
The D6S2806 locus could be suggested as a marker for linkage analysis and disease-susceptibility investigations in the MHC-DRB1 gene region.
Tumefactive multiple sclerosis: an uncommon diagnostic challenge.
- Medicine, PsychologyJournal of chiropractic medicine
Autologous hematopoietic cell transplantation for multiple sclerosis: a systematic review
- MedicineMultiple sclerosis
Patients with secondary progressive MS refractory to conventional medical treatment have longer progression-free survival following autologous stem cell transplantation with intermediate-intensity conditioning regimens than with high-intensity Conditioning regimens.
SHOWING 1-10 OF 111 REFERENCES
A genetic basis for familial aggregation in multiple sclerosis
- Medicine, PsychologyNature
Findings indicate that familial aggregation of MS is genetically determined: no effect of shared environment was detectable and the frequency of MS among first-degree non-biological relatives living with the index case was no greater than expected from Canadian population prevalence data and significantly less than for biological relatives.
Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.
- Biology, PsychologyAmerican journal of human genetics
Using family-based association analysis, statistically significant evidence is found that an SNP haplotype near APOE is associated with MS susceptibility and an analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease.
A full genome search in multiple sclerosis
- BiologyNature Genetics
The results support genetic epidemiological evidence that several genes interact epistatically to determine heritable susceptibility in multiple sclerosis.
Genetic factors and the founder effect explain familial MS in Sardinia
Data from this study indicate that MS familial aggregation in Sardinians is influenced by genetic factors and that founder effect and the isolation of Sardinia can be considered causes of the enrichment of “etiologic” MS genes.
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
- Biology, MedicineNature Genetics
Two principal regions of linkage are identified, chromosomes 17q22 and 6p21 (MHC) and these results are compatible with genetic models involving epistatic interaction between these and several additional genes, including the immunoglobulin heavy chain and T cell receptor β chain.
Genomewide scan of multiple sclerosis in Finnish multiplex families.
- BiologyAmerican journal of human genetics
Interestingly, a suggestive linkage between MS and the markers on 17q22-q24 was also revealed by a recent genomewide scan in MS families from the United Kingdom, and was detected by a two-point, parametric linkage analysis using the complete pedigree information of the 21 Finnish multiplex families.
Linkage and association analysis of chromosome 19q13 in multiple sclerosis
- Biology, PsychologyNeurogenetics
Support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele, and this effect appears to be modest with a maximum λS=1.47, probably representing no more than 10% of the overall genetic effect in MS.
The familial nature of multiple sclerosis
Although the risks are low, relatives of multiple sclerosis patients have a greater risk of developing the disease than the general population, and this observation is part of the evidence that the etiology of MS may have a genetic component.