Genetics of multiple sclerosis

@article{Dyment2004GeneticsOM,
  title={Genetics of multiple sclerosis},
  author={David A Dyment and George Cornell Ebers and A Dessa Sadovnick},
  journal={The Lancet Neurology},
  year={2004},
  volume={3},
  pages={104-110}
}
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Genetics of Multiple Sclerosis
TLDR
The genome-wide association studies in MS in large populations in combination with expression quantitative loci (eQTL) and a better understanding of the functional elements in the human genome have promoted a deeper knowledge of MS genetics in the last 10 years, but the genetic implication in the disease is still far from understanding.
Multiple Sclerosis (MS): Genetics
TLDR
Genome-wide searches for other non-HLA susceptibility genes by association have been successful in identifying many disease genes of mild effects and there are likely additional genes contributing to MS risk and new technologies may prove fruitful for their identification.
Genetics and pathogenesis of multiple sclerosis.
Genes, environment, and susceptibility to multiple sclerosis
Genetics of multiple sclerosis.
Genomic Evaluation of Multiple Sclerosis
The HLA-DRB1 Alleles Effects on Multiple Sclerosis:a Systematic Review
TLDR
There is an important relation between HLA-DRB1 and MS in diverse population groups and complementary studies are needed to know better the importance of environmental factors and its interaction with gens in the development of MS.
Genetic mapping and association analysis in multiple sclerosis
TLDR
A genome-wide screen for linkage in 136 Nordic sib-pairs with multiple sclerosis showed increased support for suggestive linkage on 10p15 (MLS 2.5), and an association analysis of the gene coding for the alpha-receptor of IL-15 (IL-15RA) showed no association.
Genetic factors and multiple sclerosis in the Moroccan population: a role for HLA class II.
Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach.
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References

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TLDR
The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found, but no single region has been identified with a major influence on familial risk.
Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene
Sharing of a conserved haplotype suggests a susceptibility gene for multiple sclerosis at chromosome 17p11
TLDR
The data suggests a novel susceptibility gene for MS in chromosome 17p11 in the northern-most part of Sweden, which demonstrates a high incidence of MS, using haplotype sharing analysis.
Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles.
Factors influencing sib risks for Multiple Sclerosis
TLDR
It is suggested that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS.
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TLDR
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Linkage analysis conditional on HLA status in a large North American pedigree supports the presence of a multiple sclerosis susceptibility locus on chromosome 12p12.
TLDR
A pedigree of Pennsylvania Dutch extraction is identified, in which MS segregates with an autosomal dominant inheritance pattern, and data suggests that both HLA DR15, DQ6 and a novel locus on chromosome 12p12 may be necessary for development of MS in this family.
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TLDR
To determine which of the original genomic locations presented in the US genome screen could be replicated, a more detailed analysis of additional families was performed and support linkage to chromosomes 6p21, 6q27, and 19q13 with LOD scores>3.0, and suggest that regions on chromosomes 12q23-24 and 16p13 may also harbor susceptibility loci for MS.
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A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
TLDR
A two-stage, multi-analytical genomic screen to identify genomic regions potentially harbouring MS susceptibility genes suggested that a multifactorial aetiology, including both environmental and multiple genetic factors of moderate effect, is more likely than a simple mendelian disease gene(s).
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