Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene.

@article{Hook2000GeneticsOM,
  title={Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene.},
  author={Lauren M Hook and Yelena Agafonova and Susan R Ross and Stephen John Turner and Tatyana V. Golovkina},
  journal={Journal of virology},
  year={2000},
  volume={74 19},
  pages={8876-83}
}
Retroviruses are believed to induce tumors by acting as insertional mutagens that activate expression of cellular protooncogenes. Indeed, almost 90% of mouse mammary tumor virus (MMTV)-induced mammary tumors in C3H/He mice show upregulation of Int protooncogenes. We have analyzed three different MMTV variants [MMTV(C3H), MMTV(HeJ), and a genetically engineered MMTV hybrid provirus (HP)] for tumorigenicity in mice from two distinct genetic backgrounds. All three viruses were tumor causing in… CONTINUE READING
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