Genetics of lymphatic anomalies.

@article{Brouillard2014GeneticsOL,
  title={Genetics of lymphatic anomalies.},
  author={Pascal Brouillard and Laurence Myriam Boon and Miikka Vikkula},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 3},
  pages={898-904}
}
Lymphatic anomalies include a variety of developmental and/or functional defects affecting the lymphatic vessels: sporadic and familial forms of primary lymphedema, secondary lymphedema, chylothorax and chylous ascites, lymphatic malformations, and overgrowth syndromes with a lymphatic component. Germline mutations have been identified in at least 20 genes that encode proteins acting around VEGFR-3 signaling but also downstream of other tyrosine kinase receptors. These mutations exert their… CONTINUE READING
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