Genetics of lymphatic anomalies.

  title={Genetics of lymphatic anomalies.},
  author={Pascal Brouillard and Laurence Myriam Boon and Miikka Vikkula},
  journal={The Journal of clinical investigation},
  volume={124 3},
Lymphatic anomalies include a variety of developmental and/or functional defects affecting the lymphatic vessels: sporadic and familial forms of primary lymphedema, secondary lymphedema, chylothorax and chylous ascites, lymphatic malformations, and overgrowth syndromes with a lymphatic component. Germline mutations have been identified in at least 20 genes that encode proteins acting around VEGFR-3 signaling but also downstream of other tyrosine kinase receptors. These mutations exert their… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 42 extracted citations


Publications referenced by this paper.
Showing 1-10 of 87 references

Mulliken and Young’s Vascular Anomalies, Hemangiomas and Malformations

  • JB Mulliken, PE Burrows, SJ Fishman, eds
  • 2013
1 Excerpt

Mutation in two siblings, one manifesting lymphedema-cholestasis syndrome, and the other, fetal hydrops

  • S Shah
  • PLoS One
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…