Genetics of leukocyte telomere length and its role in atherosclerosis.

  title={Genetics of leukocyte telomere length and its role in atherosclerosis.},
  author={Abraham Aviv},
  journal={Mutation research},
  volume={730 1-2},
Humans display a large inter-individual variation in leukocyte telomere length (LTL), which is influenced by heredity, sex, race/ethnicity, paternal age at conception and environmental exposures. LTL dynamics (birth LTL and its age-dependent attrition thereafter) mirror telomere dynamics in hematopoietic stem cells (HSCs). LTL at birth is evidently a major determinant of LTL throughout the human lifespan, such that individuals endowed with short (or long) LTL at birth probably have short (or… CONTINUE READING
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