Genetics of kidney development.

  title={Genetics of kidney development.},
  author={Peter Ekblom},
  journal={Current opinion in nephrology and hypertension},
  volume={5 3},
  • Peter Ekblom
  • Published 1996 in Current opinion in nephrology and hypertension
Genetic approaches have clarified the molecular basis of many different stages of kidney development with considerable clarity. By introducing targeted mutations in mice, a number o transcription growth factors have been shown to be required for early kidney tubulogenesis. Most recently, the transcription factor Pax-2, and bone morphogenetic protein-7, a growth factor, were added to the list of factors required for the early stages of kidney tubulogenesis. Compared with the defects seen in mice… CONTINUE READING
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