Genetics of inflammatory bowel disease: beyond NOD2.

  title={Genetics of inflammatory bowel disease: beyond NOD2.},
  author={Ma{\vs}a Umiċeviċ Mirkov and Bram Verstockt and Isabelle Cleynen},
  journal={The lancet. Gastroenterology & hepatology},
  volume={2 3},
The study of the genetic underpinnings of inflammatory bowel disease has made great progress since the identification of NOD2 as a major susceptibility gene. Novel genotyping and sequencing technologies have led to the discovery of 242 common susceptibility loci, 45 of which have been fine-mapped to statistically conclusive causal variants; 50 genes associated with very-early-onset inflammatory disease have been identified. The evolving genetic architecture of inflammatory bowel disease has… CONTINUE READING
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