Genetics of inclusion-body myositis.

  title={Genetics of inclusion-body myositis.},
  author={Merrilee Needham and Francis L Mastaglia and Michael J. Garlepp},
  journal={Muscle & nerve},
  volume={35 5},
Sporadic inclusion-body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet-unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility… CONTINUE READING

Similar Papers

Loading similar papers…