Genetics of impulse control disorders in Parkinson’s disease

@article{Cormier2012GeneticsOI,
  title={Genetics of impulse control disorders in Parkinson’s disease},
  author={Florence Cormier and Julia Muellner and Jean-Christophe Corvol},
  journal={Journal of Neural Transmission},
  year={2012},
  volume={120},
  pages={665-671}
}
Impulse control disorders (ICD) have been recognised in Parkinson’s disease (PD) as adverse effects of dopamine replacement therapy, particularly with dopamine agonists. Although virtually all PD patients are treated with dopaminergic drugs, only a minority will develop hyperdopaminergic states, suggesting predisposing and/or protecting factors. The age at onset, the sex and the dose or type of dopaminergic drugs have been identified as clinical predictive factors. Recent genetic studies have… Expand
Impulse control disorders in Parkinson’s disease
TLDR
Specific evaluation tools have now been designed to better evaluate the severity and impact of impulse control disorders in Parkinson’s disease, although features unique to PD have been identified in patients with ICD. Expand
Neurobiology and clinical features of impulse control failure in Parkinson’s disease
TLDR
Early screening for neuropsychiatric fluctuations, reduction of DA, fractionating levodopa dosage, education of patients and their relatives, are the key strategies for diagnosis and management of ICDs and related disorders. Expand
Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson’s Disease
TLDR
Using an advanced statistical approach, SNPs in nine genes, including a novel polymorphism in DRD1, are identified with potential application for the identification of PD patients at risk for ICDs. Expand
Clinical-genetic model predicts incident impulse control disorders in Parkinson's disease
TLDR
The results show that adding a candidate genetic panel increases ICD predictability, suggesting potential for developing clinical-genetic models to identify patients with PD at increased risk of ICD development and guide DRT management. Expand
Hyperdopaminergic behavioral spectrum in Parkinson's disease: A review.
TLDR
While early detection of changes in behavior, less use of dopamine agonists that have a relative selectivity for mesocorticolimbic dopamine receptors, and fractionation of levodopa dosages to avoid non-physiological pulsatile stimulation of dopamine receptors are key strategies in the management of this hyperdopaminergic behavioral spectrum, other complementary approaches are also addressed in this review. Expand
Impulse control disorders and related behaviors in Parkinson's disease: risk factors, clinical and genetic aspects, and management
TLDR
Regular monitoring of ICDRB during the course of Parkinson's disease is needed, particularly in the subject at high risk of developing these complications, and Precision medicine will require the appropriate use of machine learning to be reached in the clinical setting. Expand
Parkinson’s disease management and impulse control disorders: current state and future perspectives
TLDR
This review mainly focusses on the most common ICDs in the context of currently accepted management strategies for PD and emphasizes areas of controversy in need of further research. Expand
Polymorphisms of Dopamine Receptor Genes and Parkinson’s Disease: Clinical Relevance and Future Perspectives
TLDR
The role of DR in the modulation of peripheral immunity, in light of the emerging role of the peripheral immune system in PD pathophysiology, is examined. Expand
Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease
TLDR
An overview of recent advances in neuroimaging, electrophysiological and biochemical studies in animal models, and together with psychopharmacological assessments, are providing new insights into the brain status of impulsive behavior in patients with Parkinson's disease. Expand
A systematic review of impulse control disorders in Parkinson's disease.
TLDR
A systematic overview of literature published between 2000 and January 2013 reporting impulse control disorders in Parkinson's disease is presented and prevalence rates and the functional neuroanatomy, the impact of dopamine-serotonin interactions, and the cognitive symptomatology associated with impulse control Disorders in Parkinson’s disease are discussed. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 88 REFERENCES
Role of genetic polymorphisms of the dopaminergic system in Parkinson's disease patients with impulse control disorders.
TLDR
Polymorphisms of dopaminergic genes do not play a relevant role in the development of ICD in PD suggesting that ICD originate from inability to filter inappropriate behaviors triggered by dopaminaergic therapy. Expand
Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.
TLDR
Dopamine agonist treatment in PD is associated with 2- to 3.5-fold increased odds of having an ICD, which represents a drug class relationship across ICDs. Expand
Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease
TLDR
Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD, and carriage of either AA genotype ofDRD3 or CC genotypes of GRin2B was identified as an independent risk factor for I CRB. Expand
Dopamine Receptor D4 Polymorphism Predicts the Effect of L-DOPA on Gambling Behavior
TLDR
Findings demonstrate that genetic variation in the DRD4 gene determines an individual's gambling behavior in response to a dopaminergic drug challenge and may have implications for the treatment of Parkinson's disease patients by offering a genotype approach for determining individual susceptibilities for pathological gambling. Expand
Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease.
TLDR
The data support a possible contribution of genetic variation in the HTR2A to the susceptibility to impulse control and repetitive behaviors in Parkinson's disease. Expand
Association of attention-deficit disorder and the dopamine transporter gene.
Attention-deficit hyperactivity disorder (ADHD) has been shown to be familial and heritable, in previous studies. As with most psychiatric disorders, examination of pedigrees has not revealed aExpand
Dopamine Genes and Pathological Gambling in Discordant Sib-Pairs
TLDR
The results suggest the association of PG with DRD1 −800 T/C allele T (P = .03) and the dopamine transporter gene (SCL6A3 40 bp VNTR). Expand
Genetics of dopamine receptors and drug addiction: a comprehensive review
TLDR
Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans. Expand
Genetics of dopamine receptors and drug addiction
Dopamine plays a key role in reward behavior, yet the association of drug dependence as a chronic, relapsing disorder with the genes encoding the various dopaminergic receptor subtypes remainsExpand
Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder.
TLDR
The present findings suggest that polymorphic variation in the gene encoding the D4 dopamine receptor may be a contributing factor in the expression of symptoms associated with ADHD. Expand
...
1
2
3
4
5
...