Genetics of immune-mediated adverse drug reactions: a comprehensive and clinical review.

@article{Yip2015GeneticsOI,
  title={Genetics of immune-mediated adverse drug reactions: a comprehensive and clinical review.},
  author={Vincent L M Yip and Ana Alfirevic and Munir Pirmohamed},
  journal={Clinical reviews in allergy & immunology},
  year={2015},
  volume={48 2-3},
  pages={165-75}
}
Adverse drug reactions (ADRs) are common and are a major problem in drug therapy. Patients experience unnecessary morbidity and mortality whilst many effective drugs are withdrawn because of ADRs in a minority of patients. Recent studies have demonstrated significant associations between human leukocyte antigens (HLA) and predisposition to ADRs such as drug-induced skin injury (DISI) and drug-induced liver injury (DILI). HLA-B*58:01 has been significantly associated with allopurinol-induced… CONTINUE READING
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