Genetics of human systemic lupus erythematosus: the emerging picture.

  title={Genetics of human systemic lupus erythematosus: the emerging picture.},
  author={Swapan K. Nath and Jeff Kilpatrick and John Barker Harley},
  journal={Current opinion in immunology},
  volume={16 6},
Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease with partially understood etiology, which can affect virtually any organ. Despite suggestions to the contrary, SLE is proving to be a reliable phenotype for genetic studies. Similar to many other autoimmune diseases, SLE demonstrates a complex pattern of inheritance that is consistent with the involvement of multiple susceptibility genes as well as environmental risk factors. During the past several years, some new… CONTINUE READING