Genetics of human situs abnormalities.

@article{Casey2001GeneticsOH,
  title={Genetics of human situs abnormalities.},
  author={Brett Casey},
  journal={American journal of medical genetics},
  year={2001},
  volume={101 4},
  pages={356-8}
}
  • Brett Casey
  • Published 2001 in American journal of medical genetics
Human left-right malformations are usually sporadic, but many familial cases have been described. Recognition of these families as well as sporadic cases with underlying cytogenetic abnormalities suggest genetic predisposition for many instances of situs malformations. Studies in nonhuman vertebrates have led to the discovery of several genes conserved in normal left-right development, and mutations in some of these have been identified in humans. In addition, positional cloning efforts have… CONTINUE READING
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