Genetics of hereditary diffuse gastric cancer: progress and future challenges.

@article{Suriano2006GeneticsOH,
  title={Genetics of hereditary diffuse gastric cancer: progress and future challenges.},
  author={Gianpaolo Suriano and Paulo Ferreira and Ana Rita Mateus and Joana Correia and L Magalli Pinto Henriques and Raquel Seruca},
  journal={Future oncology},
  year={2006},
  volume={2 3},
  pages={363-70}
}
Hereditary diffuse gastric cancer (HDGC) is a rare cancer susceptibility syndrome. One third of HDGC syndrome families carry germline mutations of the E-cadherin gene. Owing to the limitation of the current endoscopic screening techniques and since no chemoprevention is yet available, total prophylactic gastrectomy is the only option offered to carriers of inactivating mutations in genetic counseling. In this regard, 30% of the E-cadherin germline mutations reported to date are of the missense… CONTINUE READING