Genetics of heart development.

  title={Genetics of heart development.},
  author={Jau-Nian Chen and Mark C Fishman},
  journal={Trends in genetics : TIG},
  volume={16 9},
The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila 'heart' is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components.