Genetics of gene expression in CNS.

@article{Pandey2014GeneticsOG,
  title={Genetics of gene expression in CNS.},
  author={Ashutosh Pandey and Robert W. Williams},
  journal={International review of neurobiology},
  year={2014},
  volume={116},
  pages={
          195-231
        }
}
Transcriptome studies have revealed a surprisingly high level of variation among individuals in expression of key genes in the CNS under both normal and experimental conditions. Ten-fold variation is common, yet the specific causes and consequences of this variation are largely unknown. By combining classic gene mapping methods-family linkage studies and genomewide association-with high-throughput genomics, it is now possible to define quantitative trait loci (QTLs), single-gene variants, and… CONTINUE READING
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