Genetics of familial Amyotrophic lateral sclerosis.

  title={Genetics of familial Amyotrophic lateral sclerosis.},
  author={Nicola Ticozzi and Cinzia Tiloca and Claudia Morelli and Claudia Colombrita and Barbara Poletti and Alberto Doretti and Luca Maderna and Stefano Messina and Antonia Ratti and Vincenzo Silani},
  journal={Archives italiennes de biologie},
  volume={149 1},
Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. About 10% of all ALS cases are familial (FALS), and constitute a clinically and genetically heterogeneous entity. To date, FALS has been linked to mutations in 10 different genes and to four additional chromosomal loci. Research on FALS genetics, and in particular the discoveries of mutations in the SOD1… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.
119 Citations
91 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 119 extracted citations


Publications referenced by this paper.
Showing 1-10 of 91 references

Mutational analysis of TARDBP in neurodegenerative diseases

  • N. Ticozzi, L. LeclercA., +6 authors H. BrownR.
  • 2009
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…