Genetics of diabetic nephropathy.

  title={Genetics of diabetic nephropathy.},
  author={Miroslav Merta and Jana Reiterov{\'a} and Romana Ry{\vs}av{\'a} and D Kmentov{\'a} and Vladim{\'i}r Tesař},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={18 Suppl 5},
Diabetic nephropathy (DN) develops in approximately 40% of type 1 diabetic patients and is a leading cause of end-stage renal failure. Its rate of progression varies greatly among individuals. Several factors, including genetic predisposition, metabolic and haemodynamic alterations and various growth factors, may contribute to the initiation and progression of DN. The genetic background of DN is believed to be polygenic. Polymorphisms of different genes, mainly from the renin-angiotensin system… CONTINUE READING
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