Genetics of dementia

@article{Loy2014GeneticsOD,
  title={Genetics of dementia},
  author={C. Loy and P. Schofield and A. Turner and J. Kwok},
  journal={The Lancet},
  year={2014},
  volume={383},
  pages={828-840}
}
  • C. Loy, P. Schofield, +1 author J. Kwok
  • Published 2014
  • Medicine
  • The Lancet
  • 25% of all people aged 55 years and older have a family history of dementia. For most, the family history is due to genetically complex disease, where many genetic variations of small effect interact to increase risk of dementia. The lifetime risk of dementia for these families is about 20%, compared with 10% in the general population. A small proportion of families have an autosomal dominant family history of early-onset dementia, which is often due to mendelian disease, caused by a mutation… CONTINUE READING
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