Genetics of dementia

  title={Genetics of dementia},
  author={C. Loy and P. Schofield and A. Turner and J. Kwok},
  journal={The Lancet},
  • C. Loy, P. Schofield, +1 author J. Kwok
  • Published 2014
  • Medicine
  • The Lancet
  • 25% of all people aged 55 years and older have a family history of dementia. For most, the family history is due to genetically complex disease, where many genetic variations of small effect interact to increase risk of dementia. The lifetime risk of dementia for these families is about 20%, compared with 10% in the general population. A small proportion of families have an autosomal dominant family history of early-onset dementia, which is often due to mendelian disease, caused by a mutation… CONTINUE READING
    195 Citations
    Frontotemporal Dementia
    • 437
    The genetics of dementia.
    • 4
    • PDF
    The Patterns of Inheritance in Early-Onset Dementia
    • 38
    Clinical exome sequencing in dementias: a preliminary study.
    • 5
    • PDF
    Overview and Current Status of Alzheimer’s Disease in Bangladesh
    • 2
    • PDF


    Genetics of dementia: Update and guidelines for the clinician
    • 35
    Familial aggregation in frontotemporal dementia
    • 183
    Phenotypic signatures of genetic frontotemporal dementia.
    • 161
    The heritability and genetics of frontotemporal lobar degeneration
    • 305
    Genetics of dementia.
    • 27
    Molecular diagnosis of autosomal dominant early onset Alzheimer’s disease: an update
    • 181
    • PDF
    Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review
    • 449
    • PDF