Genetics of congenital deafness in the Palestinian population: multiple connexin 26 alleles with shared origins in the Middle East

@article{Shahin2001GeneticsOC,
  title={Genetics of congenital deafness in the Palestinian population: multiple connexin 26 alleles with shared origins in the Middle East},
  author={H Sheykhani Shahin and Tom P Walsh and Tama Sobe and Eric D. Lynch and Mary-Claire King and Karen B. Avraham and Moien N. Kanaan},
  journal={Human Genetics},
  year={2001},
  volume={110},
  pages={284-289}
}
Abstract. In some Palestinian communities, the prevalence of inherited prelingual deafness is among the highest in the world. As an initial step towards understanding the genetic causes of hearing loss in the Palestinian population, 48 independently ascertained probands with non-syndromic hearing loss were evaluated for mutations in the connexin 26 gene. Of the 48 deaf probands, 11 (23%) were homozygous or compound heterozygous for mutations in GJB2. Five different mutations were identified… CONTINUE READING
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