Genetics of childhood disorders: XXIII. ADHD, Part 7: The serotonin system.

@article{Quist2001GeneticsOC,
  title={Genetics of childhood disorders: XXIII. ADHD, Part 7: The serotonin system.},
  author={Jennifer Quist and James L Kennedy},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2001},
  volume={40 2},
  pages={253-6}
}
253 A central premise in the “catecholamine hypothesis” of attention-deficit/hyperactivity disorder (ADHD) is that dopamine (DA) dysfunction leads to clinical symptoms. The hypothesis arises, in part, from the clinical efficacy of methylphenidate, as well as evidence from brain imaging studies that suggest reduced activity in frontal-striatal regions. The theory, however, overlooks the phenotypic complexity of the disorder and the possible interactions between the dopamine and serotonin (5-HT… CONTINUE READING