Genetics of cavernous angiomas.

  title={Genetics of cavernous angiomas.},
  author={Pierre Labauge and Christian Denier and Françoise Bergametti and Elisabeth Tournier-Lasserve},
  journal={The Lancet. Neurology},
  volume={6 3},
Cerebral cavernous malformations (CCM) are vascular malformations that can occur as a sporadic or a familial autosomal dominant disorder. Clinical and cerebral MRI data on large series of patients with a genetic form of the disease are now available. In addition, three CCM genes have been identified: CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. These recent developments in clinical and molecular genetics have given us useful information about clinical care and genetic counselling and have… CONTINUE READING
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