Genetics of brain structure and intelligence.

@article{Toga2005GeneticsOB,
  title={Genetics of brain structure and intelligence.},
  author={Arthur W. Toga and Paul M. Thompson},
  journal={Annual review of neuroscience},
  year={2005},
  volume={28},
  pages={
          1-23
        }
}
  • A. Toga, P. Thompson
  • Published 15 July 2005
  • Psychology, Medicine
  • Annual review of neuroscience
Genetic influences on brain morphology and IQ are well studied. A variety of sophisticated brain-mapping approaches relating genetic influences on brain structure and intelligence establishes a regional distribution for this relationship that is consistent with behavioral studies. We highlight those studies that illustrate the complex cortical patterns associated with measures of cognitive ability. A measure of cognitive ability, known as g, has been shown highly heritable across many studies… 

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References

SHOWING 1-10 OF 163 REFERENCES
Genetic influences on brain structure
TLDR
Detailed three-dimensional maps revealing how brain structure is influenced by individual genetic differences are reported, and may shed light on the heritability of cognitive and linguistic skills, as well as genetic liability for diseases that affect the human cortex.
Mapping genetic influences on human brain structure
TLDR
A large-scale computational brain atlas is developed, including data components from the Finnish Twin registry, to store information on individual variations in brain structure and their heritability, to motivate studies of disease in which the normative atlas acts as a quantitative reference for the heritability of structural differences and deficits in patient populations.
Neurobiology of intelligence: science and ethics
TLDR
Cognitive, psychometric, genetic and neuroimaging studies are converging, and the emergence of mechanistic models of intelligence is inevitable, and these exciting scientific advances encourage renewed responsiveness to the social and ethical implications of conducting such research.
Heritability of hippocampal size in elderly twin men: Equivalent influence from genes and environment
TLDR
It is provided novel evidence that the volume of the hippocampus, as measured on MRI, is subject to substantially less genetic control than are comparison brain regions also measured: temporal horn volume, midsagittal area of the corpus callosum, and intracranial volume.
Genetics of human prefrontal function
TLDR
This review discusses the genetics of prefrontal function within the broader concept of general cognitive ability (intelligence) and the first genes that are relevant for prefrontal function such as catechol-O-methyltransferase (COMT) are currently discovered.
Quantitative genetic modeling of variation in human brain morphology.
TLDR
Genes influencing gray and white matter overlapped to a large extent and completely determined their phenotypic correlation, and high heritability estimates that were found indicate that brain volumes may be useful as intermediate phenotypes in behavioral genetic research.
Factors Influencing the Relationship Between Brain Size and Intelligence
Publisher Summary This chapter outlines the factors that influence the relationship between brain size and intelligence. The chapter explores whether a correlation between a physical variable and IQ
The Genetics of Cognitive Processes: Candidate Genes in Humans and Animals
TLDR
It is confirmed that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition.
VI. Genome Structure and Cognitive Map of Williams Syndrome
TLDR
An integrated physical, genetic, and transcriptional map of the WMS and flanking regions is generated using multicolor metaphase and interphase fluorescence in situ hybridization of bacterial artificial chromosomes and P1 artificial chromosomes, BAC end sequencing, PCR gene marker and microsatellite, large-scale sequencing, cDNA library, and database analyses, which establish regions and consequent gene candidates for WMS features including mental retardation, hypersociability, and facial features.
Genetics of childhood disorders: III. Genetics and intelligence.
  • R. Plomin
  • Medicine, Psychology
    Journal of the American Academy of Child and Adolescent Psychiatry
  • 1999
TLDR
One new direction for genetic research on intelligence is to investigate other measures such as information-pro cessing and more direc t measures of brain function such as evoked potentials, positron em ission tomograph ic scans, and functional magnet ic resonance imaging and to explain how these measures relate to g.
...
1
2
3
4
5
...