Genetics of bipolar disorder

@article{Craddock2013GeneticsOB,
  title={Genetics of bipolar disorder},
  author={N. Craddock and P. Sklar},
  journal={The Lancet},
  year={2013},
  volume={381},
  pages={1654-1662}
}
  • N. Craddock, P. Sklar
  • Published 2013
  • Medicine
  • The Lancet
  • Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong evidence exists for a polygenic contribution to risk (ie, many risk alleles of small effect). A notable… CONTINUE READING

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