Genetics of austim: complex aetiology for a heterogeneous disorder

  title={Genetics of austim: complex aetiology for a heterogeneous disorder},
  author={Susan E B Folstein and Beth Rosen-Sheidley},
  journal={Nature Reviews Genetics},
Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again. After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, in conjunction with data from genome… 

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