Genetics of arterial hypertension and hypotension

  title={Genetics of arterial hypertension and hypotension},
  author={Dieter Rosskopf and Markus Schuerks and Christian Rimmbach and Rafael Sch{\"a}fers},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Human hypertension affects affects more than 20% of the adult population in industrialized countries, and it is implicated in millions of deaths worldwide each year from stroke, heart failure and ischemic heart disease. Available evidence suggests a major genetic impact on blood pressure regulation. Studies in monogenic hypertension revealed that renal salt and volume regulation systems are predominantly involved in the genesis of these disorders. Mutations here affect the synthesis of… CONTINUE READING