• Corpus ID: 15445338

Genetics of antisocial personality disorder : literature review

  title={Genetics of antisocial personality disorder : literature review},
  author={Tomas Mendoza and Juan Jorge Palacios Casados},
Antisocial Personality Disorder (ASPD) is characterized by an incapacity of an individual to adapt themselves to social norms. These social norms are extremely important because they govern many aspects of behavior during adolescence and adulthood. Patients with ASPD typically have irritability problems and aggressive feelings toward other people. These aggressive feelings are expressed in a context of threat and intimidation. ASPD is less common in clinical settings comparing the total… 


Genetic-environmental interaction in the genesis of aggressivity and conduct disorders.
Environmental effects and genetic-environmental interaction account for significant variability in adoptee aggressivity, conduct disorder, and adult antisocial behavior and have important implications for the prevention and intervention of conduct disorder and associated conditions such as substance abuse and aggressivity.
The adult antisocial syndrome with and without antecedent conduct disorder: comparisons from an adoption study.
The two antisocial groups were similar with respect to sociopathy scales, co-occurring diagnoses, and the incidence of most individual symptoms, however, several adult and conduct disorder symptoms had significant specific associations with biological or environmental background or their interaction.
Genetic Contributions to Antisocial Personality and Behavior: A Meta-Analytic Review From an Evolutionary Perspective
  • C. Ferguson
  • Psychology, Biology
    The Journal of social psychology
  • 2010
Evidence from behavioral genetics supports the conclusion that a significant amount of the variance in antisocial personality and behavior (APB) is due to genetic contributions, and a meta-analytic review of behavioral genetic etiological studies of APB indicated that 56% ofThe variance in APB can be explained through genetic influences.
An adoption study of antisocial personality.
  • R. Crowe
  • Psychology
    Archives of general psychiatry
  • 1974
The findings point to the importance of interactions between genetic and environmental factors in the development of antisocial personality.
Family transmission and heritability of externalizing disorders: a twin-family study.
The mechanism underlying the familial transmission of externalizing disorders is primarily a highly heritable general vulnerability, which should be the focus of research regarding the etiology and treatment of Externalizing disorders.
Impulsivity, aggression, and serotonin: a molecular psychobiological perspective.
This contribution reviews studies of major gene effects in inbred and knockout strains of mice with increased aggression-related behavior and discusses the relevance of several serotonergic gene variations in humans which include high aggressiveness as part of the phenotype.
Differential heritability of adult and juvenile antisocial traits.
Compared DSM-III-R antisocial personality disorder symptoms before vs after the age of 15 years within a sample of twins, characteristics of the shared or family environment that promote antisocial behavior during childhood and early adolescence also promote later antissocial behavior, but to a much lesser extent.
Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
  • B. Haberstick, J. Lessem, J. Hewitt
  • Psychology, Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
This work did not replicate a previous report that MAOA polymorphisms moderated the relationship between maltreatment and conduct problems, and there was, however, a non‐significant trend in the predicted direction.
Nature and Nurture Predispose to Violent Behavior: Serotonergic Genes and Adverse Childhood Environment
An interaction effect between childhood environment and 5HTT genotype on violent behavior was found in that high adversity during childhood impacted only the later-life violence if the short promoter alleles were present.
MAOA and the neurogenetic architecture of human aggression