Genetics of ankylosing spondylitis.

  title={Genetics of ankylosing spondylitis.},
  author={Matthew A Brown},
  journal={Current opinion in rheumatology},
  volume={22 2},
PURPOSE OF REVIEW Over the past 3 years, several new genes and gene deserts have been identified that are associated with ankylosing spondylitis (AS). The purpose of this review is to discuss the major findings of these studies, and the answers they provide and questions they raise about the pathogenesis of this common condition. RECENT FINDINGS Five genes/genetic regions have now definitively been associated with AS [the major histocompatibility complex (MHC), IL23R, ERAP1, 2p15 and 21q22… CONTINUE READING
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