Genetics of aminoglycocide-induced and prelingual non-syndromic mitochondrial hearing impairment: A review

@article{HemaBindu2008GeneticsOA,
  title={Genetics of aminoglycocide-induced and prelingual non-syndromic mitochondrial hearing impairment: A review},
  author={L. Hema Bindu and P. P. Reddy},
  journal={International Journal of Audiology},
  year={2008},
  volume={47},
  pages={702 - 707}
}
Pathogenic mitochondrial DNA mutations are most often implicated in inherited and acquired hearing impairment. The current review mainly focuses on the 12S rRNA mitochondrial gene mutations associated with non-syndromic deafness without or after aminoglycosides exposure. Aminoglycoside-induced and nonsyndromic deafness has been shown to have a genetic susceptibility and the pathogenic mitochondrial 12S rRNA A1555G mutation was identified as the primary factor underlying the hearing loss in many… 
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