Atopic diseases are complex multifactorial disorders involving genetic and environmental factors. It is generally accepted that atopic diseases are the results of inappropriate immunological responses to common environmental allergens in genetically susceptible individuals. Recent advances in the genetic technology allow us to perform genome-wide association studies (GWAS), and identified several novel susceptibility genes such as ORMDL3 for childhood asthma and C11orf30 for atopic dermatitis. The discovery of novel genes leads new concepts to understand disease pathogenesis. In this review, we present an overview of the recent advance of genetic technology as well as atopy-related genes discovered by genetic approach.