Genetics of alcoholism: rapid development of a new high-ethanol-preferring (HEP) strain of female and male rats.

@article{Myers1998GeneticsOA,
  title={Genetics of alcoholism: rapid development of a new high-ethanol-preferring (HEP) strain of female and male rats.},
  author={R. D. Myers and Denise E. Robinson and Malcolm J. West and Thomas A Biggs and Brian A. McMillen},
  journal={Alcohol},
  year={1998},
  volume={16 4},
  pages={343-57}
}
A genetically based animal model of alcoholism has been developed in a relatively short period of 3 years. The new strain is characterized by an intense preference for ethanol over water as well as unique behavioral, neurochemical and other attributes. This new strain, termed high-ethanol-preferring (HEP) rats, was derived initially from selective cross-breeding of a variant strain of female Harlan Sprague-Dawley (SD) rats with the outbred Wistar line of male ethanol-preferring (P) rats. In… CONTINUE READING
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