Genetics of Parkinson's disease: the yield.

@article{Spatola2014GeneticsOP,
  title={Genetics of Parkinson's disease: the yield.},
  author={Marianna Spatola and Christian Wider},
  journal={Parkinsonism & related disorders},
  year={2014},
  volume={20 Suppl 1},
  pages={S35-8}
}
The discovery of genes implicated in familial forms of Parkinson's disease (PD) has provided new insights into the molecular events leading to neurodegeneration. Clinically, patients with genetically determined PD can be difficult to distinguish from those with sporadic PD. Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations. Additional recessive forms of parkinsonism present with atypical signs, including… CONTINUE READING

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The discovery of genes implicated in familial forms of Parkinson 's disease ( PD ) has provided new insights into the molecular events leading to neurodegeneration .
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