Genetics of Mammalian Sex Chromosomes

  title={Genetics of Mammalian Sex Chromosomes},
  author={Liane Brauch Russell},
  pages={1795 - 1803}
The great strides made during the past two years in the whole field of mammalian cytogenetics have, in particular, enlarged our knowledge of the role of the mammalian sex chromosomes. The following summary briefly lists the most recent discoveries in the mouse, where genetic findings have played a relatively greater role than in the other species of mammals. The male-determining property of the mammalian Y chromosome, established earlier in mouse and man, has been further confirmed by the… 
The fifties and the renaissance in human and mammalian cytogenetics.
T HE period from 1956 to 1962 was seminal for human and mammalian cytogenetics. The human chromosome number and normal human karyotype were established, along with those of many other mammals. The
Cytogenetic considerations in animal breeding
  • N. Fechheimer
  • Biology, Medicine
    Annales de génétique et de sélection animale
  • 1971
It is concluded that the occurrence of chromosomal aberrations causes a serious reduction of potential productivity and the extent of this loss should be accurately determined and means found to reduce it.
Mary Lyon and the hypothesis of random X chromosome inactivation
The 50th anniversary of Mary Lyon’s 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunity
Mammalian X-chromosome inactivation.
A History of the Discovery of Random X Chromosome Inactivation in the Human Female and its Significance
The random inactivation of the X chromosome-bearing genes for isoenzyme types A and B of glucose-6-phosphate dehydrogenase was used to establish the clonal origin of neoplasms in informative women with leiomyomas.
Position effect variegation in the mouse.
Evidence is provided favouring the view that the X-chromosome controlling element, Xce, modifies the heterozygous phenotypes of X-linked genes by biasing the randomness of theX-inactivation process, rather than by operating through cell selection mechanisms.
Evidence for X/X chromosome translocation in humans
The phenotypic effects of an X/autosome translocation in mice were among the chief sources of evidence that led to the formulation of the single-active-X hypothesis (Lyon, 1961 ; Russell, 1961 ;
The X chromosome in development in mouse and man
  • M. Monk
  • Biology
    Journal of Inherited Metabolic Disease
  • 2005
Regions of homology between the mouse and human X chromosomes allow prediction of the map positions of homologous genes and provide mouse models of genetic disease in the human.
  • 2022


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