Genetics of Mammalian Sex Chromosomes

@article{Russell1961GeneticsOM,
  title={Genetics of Mammalian Sex Chromosomes},
  author={Liane Brauch Russell},
  journal={Science},
  year={1961},
  volume={133},
  pages={1795 - 1803}
}
The great strides made during the past two years in the whole field of mammalian cytogenetics have, in particular, enlarged our knowledge of the role of the mammalian sex chromosomes. The following summary briefly lists the most recent discoveries in the mouse, where genetic findings have played a relatively greater role than in the other species of mammals. The male-determining property of the mammalian Y chromosome, established earlier in mouse and man, has been further confirmed by the… 
The fifties and the renaissance in human and mammalian cytogenetics.
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Mammalian X-chromosome inactivation.
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The random inactivation of the X chromosome-bearing genes for isoenzyme types A and B of glucose-6-phosphate dehydrogenase was used to establish the clonal origin of neoplasms in informative women with leiomyomas.
Position effect variegation in the mouse.
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Evidence is provided favouring the view that the X-chromosome controlling element, Xce, modifies the heterozygous phenotypes of X-linked genes by biasing the randomness of theX-inactivation process, rather than by operating through cell selection mechanisms.
Evidence for X/X chromosome translocation in humans
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Regions of homology between the mouse and human X chromosomes allow prediction of the map positions of homologous genes and provide mouse models of genetic disease in the human.
OF THE UNITED-NAXI-ONS .
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References

Principles of Human Genetics (Freeman
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