Genetics of IL-13 and functional relevance of IL-13 variants.

  title={Genetics of IL-13 and functional relevance of IL-13 variants.},
  author={Donata Vercelli},
  journal={Current opinion in allergy and clinical immunology},
  volume={2 5},
  • Donata Vercelli
  • Published 2002 in
    Current opinion in allergy and clinical…
Studies in both humans and mice clearly show that interleukin (IL)-13 is a central regulator of allergic inflammation. Numerous single nucleotide polymorphisms have been recently identified in the IL-13 gene and have been found to be associated with allergic and/or asthmatic phenotypes in different populations throughout the world. Furthermore, functional genomics studies are highlighting mechanistic pathways that may link genetic variation in IL-13 and disease. IL-13 is therefore an ideal… CONTINUE READING

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