Genetics of Human Taste Perception

@article{Kim2004GeneticsOH,
  title={Genetics of Human Taste Perception},
  author={Un-Kyung Kim and Paul A. S. Breslin and Danielle R. Reed and Dennis Drayna},
  journal={Journal of Dental Research},
  year={2004},
  volume={83},
  pages={448 - 453}
}
Genetic approaches are rapidly yielding new information about our sense of taste. This information comes from both molecular studies of genes encoding taste receptors and other taste-signaling components, and from studies of inherited variation in taste abilities. Our understanding of bitter taste has advanced by combined information from discovery and study of the TAS2R family of taste receptor genes, hand in hand with genetic linkage and positional cloning studies, notably on the ability to… Expand
Human taste genetics.
  • D. Drayna
  • Biology, Medicine
  • Annual review of genomics and human genetics
  • 2005
TLDR
Improvement in the understanding of taste at the molecular level has provided an understanding of variation in the ability to taste phenylthiocarbamide (PTC), and has resolved long-standing controversies about the genetics of this classic human genetic trait. Expand
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Taste receptors function as one of the interfaces between internal and external milieus. Taste receptors for sweet and umami (T1R [taste receptor, type 1]), bitter (T2R [taste receptor, type 2]), andExpand
Molecular basis of bitter taste
TLDR
The functional characterization of some of the receptors that these genes encode suggests that it will be possible to understand more precisely their specific functions and to address unresolved questions in bitter taste. Expand
Genetic variation in taste and its influence on food selection.
TLDR
The present state of knowledge of the genetic variation in taste is summarized, and how such variation might influence food intake behaviors is summarized. Expand
Genetics and Evolution of Taste
TLDR
Comparative analysis of the T1R and T2R genes suggests that their evolution was a dynamic process of adaptation of different species to their chemical environments and feeding ecology, with large expansions and contractions of gene families in different animal lineages. Expand
Genetic basis of flavor sensitivity and food preferences
TLDR
This chapter focuses on recent findings on the polymorphisms in chemosensory genes, and their association to flavor sensitivity and food preferences, including the most studied bitter taste receptor TAS2R38. Expand
Molecular Basis of Taste Sense: Involvement of GPCR Receptors
TLDR
The current state of knowledge about the involvement of G protein coupled receptors (GPCRs) in taste sensing and intracellular signaling is reviewed. Expand
Genetics of sweet taste preferences.
Inbred mouse strains display marked differences in avidity for sweet solutions due in part to genetic differences among strains. Using several techniques, we have located a number of regionsExpand
A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health
TLDR
Overall, these SNPs in taste receptors associated with fat, sweet, bitter, umami, and salt taste modalities and their contributions to food preferences, and chronic disease demonstrate the potential to influence food preferences and consequently health. Expand
Genetic influences on taste
[Extract] As consumers, our sensory and hedonic experiences of foods and beverages are most often of an overall flavour percept that depends upon the integration of multiple, distinct sensoryExpand
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Taste receptor cells respond to gustatory stimuli using a complex arrangement of receptor molecules, signaling cascades, and ion channels. When stimulated, these cells produce action potentials thatExpand
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