Genetics of Human Cardiovascular Disease

@article{Kathiresan2012GeneticsOH,
  title={Genetics of Human Cardiovascular Disease},
  author={Sekar Kathiresan and Deepak Srivastava},
  journal={Cell},
  year={2012},
  volume={148},
  pages={1242-1257}
}
Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease, most of which are heritable. Enormous effort has been invested in understanding the genes and specific DNA sequence variants that are responsible for this heritability. Here, we review the lessons learned for monogenic and common, complex forms of cardiovascular disease. We also discuss key challenges that remain for gene discovery and for moving from genomic localization… CONTINUE READING
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