Genetics of Hirschsprung disease and anorectal malformations.

  title={Genetics of Hirschsprung disease and anorectal malformations.},
  author={Erin A Mundt and Michael David Bates},
  journal={Seminars in pediatric surgery},
  volume={19 2},
Hirschsprung disease (HD) and anorectal malformations (ARMs) result from alterations in hindgut development. It has long been recognized that both recur in families and thus result, at least in part, from genetic factors. Progress in the understanding of the genetic basis of HD has been made by the application of findings from genetic animal models of altered enteric nervous system development to human beings. Several genes have been shown to be important for human enteric nervous system… CONTINUE READING


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