Genetics of Addiction: Future Focus on Gene × Environment Interaction?

  title={Genetics of Addiction: Future Focus on Gene × Environment Interaction?},
  author={Jacqueline M. Vink},
  journal={Journal of studies on alcohol and drugs},
  volume={77 5},
The heritability of substance use is moderate to high. Successful efforts to find genetic variants associated with substance use (smoking, alcohol, cannabis) have been undertaken by large consortia. However, the proportion of phenotypic variance explained by the identified genetic variants is small. Interestingly, there is overlap between the genetic variants that influence different substances. Moreover, there are sets of "substance-specific" genes and sets of genes contributing to a… CONTINUE READING