Genetics in autoimmune hepatitis.

  title={Genetics in autoimmune hepatitis.},
  author={Peter T. Donaldson},
  journal={Seminars in liver disease},
  volume={22 4},
Current hypotheses suggest that autoimmune hepatitis (AIH) is triggered by an environmental factor in a genetically susceptible host. Multiple genes may interact to produce a "permissive gene pool" that determines both disease risk and phenotype. Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region. Three different molecular models have been proposed based on histidine at DRbeta13, lysine at DRbeta71, and valine at DRbeta86… CONTINUE READING
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