Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.

@article{Rutsch2011GeneticsIA,
  title={Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.},
  author={Frank Rutsch and Yvonne Nitschke and Robert A. Terkeltaub},
  journal={Circulation research},
  year={2011},
  volume={109 5},
  pages={578-92}
}
Artery calcification reflects an admixture of factors such as ectopic osteochondral differentiation with primary host pathological conditions. We review how genetic factors, as identified by human genome-wide association studies, and incomplete correlations with various mouse studies, including knockout and strain analyses, fit into "pieces of the puzzle" in intimal calcification in human atherosclerosis, and artery tunica media calcification in aging, diabetes mellitus, and chronic kidney… CONTINUE READING