Genetics and visceral leishmaniasis: of mice and man.

@article{Blackwell2009GeneticsAV,
  title={Genetics and visceral leishmaniasis: of mice and man.},
  author={Jenefer M Blackwell and Michaela Fakiola and M E Ibrahim and Sarra Elisabeth Jamieson and Selma M B Jeronimo and E. Nancy Miller and Abhishek K. Mishra and Hiba S Mohamed and Christopher Sean Peacock and M. Putta Raju and Shanmuga Sundar and Mary E Wilson},
  journal={Parasite immunology},
  year={2009},
  volume={31 5},
  pages={254-66}
}
Ninety per cent of the 500,000 annual new cases of visceral leishmaniasis (VL) occur in India/Bangladesh/Nepal, Sudan and Brazil. Importantly, 80-90% of human infections are sub-clinical or asymptomatic, usually associated with strong cell-mediated immunity. Understanding the environmental and genetic risk factors that determine why two people with the same exposure to infection differ in susceptibility could provide important leads for improved therapies. Recent research using candidate gene… CONTINUE READING

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