Genetics and the understanding of selection

  title={Genetics and the understanding of selection},
  author={L. Hurst},
  journal={Nature Reviews Genetics},
  • L. Hurst
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Genetics
  • At first sight selection is a simple notion, and some consider it the most important evolutionary force. But how important is selection, is it really so trivial to understand and what are the alternatives? Here I discuss how genetics is crucial for addressing all of these questions: genetics allowed the concept of natural selection to become viable, it contributed to our understanding of the complexities of selection and it spurred the development of competing models of evolution. Understanding… CONTINUE READING
    116 Citations

    Figures from this paper

    The impact of natural selection on health and disease: uses of the population genetics approach in humans
    • 33
    The role played by natural selection on Mendelian traits in humans
    • 17
    Evolution: The routes of adaptation
    • T. Casci
    • Biology
    • Nature Reviews Genetics
    • 2009
    • 2
    The evolution of gene duplications: classifying and distinguishing between models
    • 933
    • PDF
    On the importance of balancing selection in plants.
    • 109
    • PDF
    The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach
    • 5
    • PDF
    The locus of sexual selection: moving sexual selection studies into the post‐genomics era
    • 37
    • PDF
    Comparative analyses of adaptive phenomena in eukaryotic systems
    • PDF


    Molecular signatures of natural selection.
    • R. Nielsen
    • Biology, Medicine
    • Annual review of genetics
    • 2005
    • 1,332
    • PDF
    Slightly Deleterious Mutant Substitutions in Evolution
    • 883
    Recent and ongoing selection in the human genome
    • 458
    • PDF
    The neutral theory is dead. Long live the neutral theory.
    • M. Kreitman
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 1996
    • 129
    The cost of natural selection
    • 310
    Anti-cancer selection as a source of developmental and evolutionary constraints.
    • F. Galis, J. Metz
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2003
    • 41
    • PDF
    Development of Neutral and Nearly Neutral Theories
    • Ohta, Gillespie
    • Biology, Medicine
    • Theoretical population biology
    • 1996
    • 227
    • PDF
    Darwinian adaptation, population genetics and the streetcar theory of evolution
    • 178