Genetics and the common cancers.

  title={Genetics and the common cancers.},
  author={Julian Peto and Richard S. Houlston},
  journal={European journal of cancer},
  volume={37 Suppl 8},
Rare highly penetrant genes cannot account for much of the familial risk for most common cancers, and there is increasing evidence that a high proportion of cancers arise in a susceptible minority who carry low-penetrance genes or gene combinations. The evidence for the existence of such genes and the prospects for identifying them are reviewed. 
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