Genetics and smoking cessation improving outcomes in smokers at risk.

  title={Genetics and smoking cessation improving outcomes in smokers at risk.},
  author={Caryn E. Lerman and Robert Schnoll and Marcus R Munaf{\`o}},
  journal={American journal of preventive medicine},
  volume={33 6 Suppl},
This article reviews evidence supporting the potential utility of a pharmacogenetic approach to the treatment of nicotine dependence. There is substantial evidence that nicotine dependence and smoking persistence are heritable, and are determined by a complex interplay of polygenic and environmental influences. The most robust evidence for specific genetic influences on nicotine dependence is found in studies of genetic variation in nicotine-metabolizing enzymes. Data also support the role of… CONTINUE READING

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