Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.

@article{Ochsner2000GeneticsAR,
  title={Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.},
  author={Urs A Ochsner and Zane Johnson and Michael L. Vasil},
  journal={Microbiology},
  year={2000},
  volume={146 ( Pt 1)},
  pages={185-98}
}
A gene cluster similar to haem iron uptake loci of bacterial pathogens was identified in Pseudomonas aeruginosa. This phu locus ('Pseudomonas haem uptake') consisted of the phuR receptor gene and the phuSTUVW operon encoding a typical ABC transporter. Expression of phuR and phuSTUVW from mapped transcriptional-start sites occurred under iron-restricted growth conditions and was directly controlled by the Fur protein. Binding of Fur was demonstrated by DNase footprinting of two adjacent 'Fur… CONTINUE READING
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