Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline.

@article{Brandriss1979GeneticsAP,
  title={Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline.},
  author={Marjorie C. Brandriss and Boris Magasanik},
  journal={Journal of bacteriology},
  year={1979},
  volume={140 2},
  pages={498-503}
}
Proline is converted to glutamate in the yeast Saccharomyces cerevisiae by the sequential action of two enzymes, proline oxidase and delta 1-pyrroline-5-carboxylate (P5C) dehydrogenase. The levels of these enzymes appear to be controlled by the amount of proline in the cell. The capacity to transport proline is greatest when the cell is grown on poor nitrogen sources, such as proline or urea. Mutants have been isolated which can no longer utilize proline as the sole source of nitrogen. Mutants… CONTINUE READING

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