Genetics and pharmacogenetics of aminergic transmitter pathways in functional gastrointestinal disorders.

Abstract

Functional gastrointestinal disorders (FGIDs) are highly prevalent syndromes, without evident underlying organic causes. Their pathogenesis is multifactorial in nature, with a combination of environmental and genetic factors contributing to their clinical manifestations, for which most of current treatments are not satisfactory. It is acknowledged that amine mediators (noradrenaline, dopamine and serotonin) play pivotal regulatory actions on gut functions and visceral sensation. In addition, drugs of therapeutic interest for FGIDs act on these transmitter pathways. The present article reviews current knowledge on the impact of genetics and pharmacogenetics of aminergic pathways on FGID pathophysiology, clinical presentations, symptom severity and medical management, in an attempt of highlighting the most relevant evidence and point out issues that should be addressed in future investigations.

DOI: 10.2217/pgs.15.12

Cite this paper

@article{Martinucci2015GeneticsAP, title={Genetics and pharmacogenetics of aminergic transmitter pathways in functional gastrointestinal disorders.}, author={Irene Martinucci and Corrado Blandizzi and Nicola de Bortoli and Massimo Bellini and Luca Antonioli and Marco Tuccori and Matteo Fornai and Santino Marchi and Rocchina Colucci}, journal={Pharmacogenomics}, year={2015}, volume={16 5}, pages={523-39} }