Genetics and neuropathology of Huntington's disease.

  title={Genetics and neuropathology of Huntington's disease.},
  author={Anton Reiner and Ioannis Dragatsis and Paula Dietrich},
  journal={International review of neurobiology},
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral and motor decline. The basis of HD is a CAG repeat expansion to >35 CAG in a gene that codes for a ubiquitous protein known as huntingtin, resulting in an expanded N-terminal polyglutamine tract. The size of the expansion is correlated with disease severity, with increasing CAG accelerating the age of onset. A variety… CONTINUE READING
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