Genetics and molecular biology of chitin synthesis in fungi.

  title={Genetics and molecular biology of chitin synthesis in fungi.},
  author={Christine E. Bulawa},
  journal={Annual review of microbiology},
In Saccharomyces cerevisiae, three chitin synthases have been detected. Chitin synthases I and II, the products of the CHS1 and CHS2 genes, respectively, are closely related proteins that require partial proteolysis for activity in vitro. In contrast, chitin synthase III is active in vitro without protease treatment, and three genes, CSD2 (= CAL1), CSD4 (= CAL2), and CAL3, are required for its activity. In the cell, the three enzymes have different functions. Chitin synthase I and II make only… CONTINUE READING
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