Genetics and molecular biology of carotenoid pigment biosynthesis

@article{Armstrong1996GeneticsAM,
  title={Genetics and molecular biology of carotenoid pigment biosynthesis},
  author={Gregory A. Armstrong and J. E. Hearst},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={228 - 237}
}
The crucial roles of carotenoids and their metabolites in photooxidative protection and photosynthesis, not to mention nutrition, vision, and cellular differentiation, make them an important and complex class of biological pigments. Significant advances within the last few years have enhanced our understanding of the genetics and molecular biology of carotenoid biosynthesis in bacteria, fungi, algae, and plants. All of the genes involved in carotenoid biosynthesis from Rhodobacter capsulatus… 

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References

SHOWING 1-10 OF 100 REFERENCES

Conserved enzymes mediate the early reactions of carotenoid biosynthesis in nonphotosynthetic and photosynthetic prokaryotes.

TLDR
The nucleotide sequence of three genes from the carotenoid biosynthesis gene cluster of Erwinia herbicola are reported, which encode homologs of the CrtB, CrtE, and CrtI proteins of Rhodobacter capsulatus, a purple nonsulfur photosynthetic bacterium, suggesting the evolutionary conservation of early enzymes from this pathway.

Regulation of carotenoid biosynthesis.

Eubacteria show their true colors: genetics of carotenoid pigment biosynthesis from microbes to plants

TLDR
The functional compatibility of enzymes from different organisms will form a central theme in the genetic engineering of carotenoid pigment biosynthetic pathways and create exciting possibilities for the directed manipulation of carOTenoid levels and content.

Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli

TLDR
The most important function of carotenoid pigments, especially beta-carotene in higher plants, is to protect organisms against photooxidative damage, and this work has elucidated for the first time the pathway for biosynthesis of theseCarotenoids at the level of enzyme-catalyzed reactions, using bacterial carOTenoid biosynthesis genes.

Molecular cloning and expression in photosynthetic bacteria of a soybean cDNA coding for phytoene desaturase, an enzyme of the carotenoid biosynthesis pathway.

TLDR
It is concluded that pds1 is a nuclear gene encoding a phytoene desaturase enzyme that, as its microbial counterparts, contains sequence motifs characteristic of flavoproteins.

Carotenoid desaturases from Rhodobacter capsulatus and Neurospora crassa are structurally and functionally conserved and contain domains homologous to flavoprotein disulfide oxidoreductases.

TLDR
The results indicate that both structure and function of carotenoid desaturases have been conserved during evolution and suggest that these enzymes are evolutionarily related to disulfide oxidoreductases.

Isolation, sequence, and characterization of the Cercospora nicotianae phytoene dehydrogenase gene

TLDR
The cloned and sequenced Cercospora nicotianae gene for the carotenoid biosynthetic enzyme phytoene dehydrogenase revealed it has greater than 50% identity with its counterpart in Neurospora crassa and is related, but more distantly, tophytoenes dehydrogenases from plants and cyanobacteria.

Early steps in carotenoid biosynthesis: sequences and transcriptional analysis of the crtI and crtB genes of Rhodobacter sphaeroides and overexpression and reactivation of crtI in Escherichia coli and R. sphaeroides

TLDR
The transcription initiation point is located and it is shown that R. sphaeroides possesses an oxygen-regulated CrtI-type phytoene desaturase gene that forms a transcriptional operon with crtB, and evidence for the existence of a crtIB operon is presented.
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